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J Am Med Inform Assoc 12:618-629 doi:10.1197/jamia.M1841
  • Original Investigation

Generating a Reliable Reference Standard Set for Syndromic Case Classification

Table 9

Generalizability Coefficients for One and Two Raters for Febrile Syndromes

Classification Generalizability Coefficient per Rater Generalizability Coefficient for Two Raters No. of Experts Required for ρ ≥ 0.70
Febrile respiratory syndrome 0.84 0.91 1
 Febrile lower respiratory 0.88 0.93 1
  Febrile radiological evidence 0.88 0.94 1
 Febrile explained by nonrespiratory or noninfectious diagnosis 0.84 0.91 1
Febrile gastrointestinal syndrome 0.88 0.94 1
 Febrile diarrhea 0.88 0.94 1
 Febrile explained by nongastrointestinal or noninfectious diagnosis 0.66 0.79 2
Febrile constitutional syndrome 0.78 0.87 1
Febrile rash syndrome 0.86 0.92 1
Febrile hemorrhagic syndrome 0.80 0.89 1
Febrile neurological syndrome 0.89 0.94 1
 Febrile meningoencephalitic 0.92 0.96 1
Febrile botulinic syndrome 0.64 0.78 2
Total of all syndromes and features (except constitutional) 0.86 0.92 1

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