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J Am Med Inform Assoc 2006;13:16-23 doi:10.1197//jamia.M1749
  • The Practice of Informatics
  • Position Paper

The Use and Interpretation of Quasi-Experimental Studies in Medical Informatics

  1. Anthony D Harris,
  2. Jessina C McGregor,
  3. Eli N Perencevich,
  4. Jon P Furuno,
  5. Jingkun Zhu,
  6. Dan E Peterson,
  7. Joseph Finkelstein
  1. Affiliations of the authors: Department of Epidemiology and Preventive Medicine, University of Maryland, Baltimore, MD (ADH, JCM, ENP, JPF, JZ, JF); VA Maryland Health Care System, Baltimore, MD (ADH, ENP); Cereplex Inc., Germantown, MD (DEP)
  1. Correspondence and reprints: Anthony D. Harris, MD, MPH, Division of Healthcare Outcomes Research, Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, 100 N. Greene Street, Lower Level, Baltimore, MD; e-mail: <aharris{at}epi.umaryland.edu>
  • Received 19 November 2004
  • Accepted 12 August 2005

Abstract

Quasi-experimental study designs, often described as nonrandomized, pre-post intervention studies, are common in the medical informatics literature. Yet little has been written about the benefits and limitations of the quasi-experimental approach as applied to informatics studies. This paper outlines a relative hierarchy and nomenclature of quasi-experimental study designs that is applicable to medical informatics intervention studies. In addition, the authors performed a systematic review of two medical informatics journals, the Journal of the American Medical Informatics Association (JAMIA) and the International Journal of Medical Informatics (IJMI), to determine the number of quasi-experimental studies published and how the studies are classified on the above-mentioned relative hierarchy. They hope that future medical informatics studies will implement higher level quasi-experimental study designs that yield more convincing evidence for causal links between medical informatics interventions and outcomes.

Footnotes

  • Dr. Harris was supported by NIH grants K23 AI01752-01A1 and R01 AI60859-01A1. Dr. Perencevich was supported by a VA Health Services Research and Development Service (HSR&D) Research Career Development Award (RCD-02026-1). Dr. Finkelstein was supported by NIH grant RO1 HL71690.

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