Pairwise Comparison and Agreement of Disease–Drug Associations
| Disease | (RCT/MeSH, RCT/UMLS) | (RCT/MeSH, DSUM/UMLS 2004) | (RCT/UMLS, DSUM/UMLS 2004) | (DSUM/UMLS 2003, DSUM/UMLS 2004) |
| Acquired immunodeficiency syndrome | (0.59, 0.65) | (0.45, 0.27) | (0.65, 0.35) | (0.94, 0.89) |
| Asthma | (0.72, 0.45) | (0.22, 0.22) | (0.28, 0.44) | (0.78, 1.00) |
| Breast neoplasms | (0.25, 1.00) | (0.25, 0.25) | (0.50, 0.12) | (1.00, 0.50) |
| Congestive heart failure | (0.66, 0.38) | (0.15, 0.57) | (0.01, 0.07) | (1.00, 0.57) |
| Diabetes mellitus | (0.72, 0.50) | (0.45, 0.23) | (0.43, 0.32) | (1.00, 0.60) |
| Parkinson’s disease | (0.27, 0.60) | (0.36, 0.36) | (1.00, 0.45) | (1.00, 0.45) |
| Pneumonia | (0.83, 0.31) | (0.20, 0.27) | (0.11, 0.40) | (0.74, 0.77) |
| Schizophrenia | (0.40, 0.40) | (0.60, 0.25) | (0.70, 0.29) | (0.78, 0.75) |
| Spearman correlation across diseases | ρ = 0.9345 | ρ = 0.2678 | ρ = 0.2619 | ρ = 0.9524 |
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(a, b) = (proportion of common drugs in a, proportion of common drugs in b) where a and b = (RCT/MeSH, RCT/UMLS, DSUM/UMLS for 2003, or DSUM/UMLS for 2004); a common drug is one that is identified by both a and b for the disease.
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In total, there are 4 different sources of 2×2 tables, giving 6 discrete pairs—e.g, (RCT/MeSH, RCT/UMLS) or (RCT/UMLS, DSUM/UMLS 2004). A drug that is identified by both sources is called common. To compute the proportion of common drugs in each source to measure agreement between the sources, the number of common drugs in each source is counted and divided by the total number of drugs identified by each source. This table presents 4 of the 6 pairs—for (RCT/MeSH, DSUM/UMLS 2003), ρ = 0.4226 and (RCT/UMLS, DSUM/UMLS 2003), ρ = 0.4226.
