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J Am Med Inform Assoc 15:794-798 doi:10.1197/jamia.M2747
  • Original Investigation

Effects of Image Compression on Automatic Count of Immunohistochemically Stained Nuclei in Digital Images

Table 1

Probability Values from Student's t-Tests Comparing Mean Counts in TIFF and JPEG Images of Different Compression Rates

Differences TIFF vs. 3× JPEG TIFF vs. 23× JPEG TIFF vs. 46× JPEG
Globally <0.001 <0.001 <0.001
No cluster/Low area cluster 0.002 0.059 0.125
Fewer than 100 nuclei 0.125 0.052 0.175
Large-area cluster <0.001 <0.001 <0.001
More than 100 nuclei <0.001 <0.001 <0.001
  • JPEG = joint photographic experts group; TIFF = tagged image file format.

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