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J Am Med Inform Assoc 16:40-46 doi:10.1197/jamia.M2808
  • The Practice of Informatics

Tiering Drug–Drug Interaction Alerts by Severity Increases Compliance Rates

Table 4

Level 2 DDIs with Disparate Compliance Rates

Drug Pair Non-Tiered Tiered
Cyclosporine & Verapamil 0.0% 60.0%
Indomethacin & Ketorolac Tromethamine 0.0% 59.5%
Theophylline Immediate Release & Levofloxacin 0.0% 55.6%
Magnesium Hydroxide & Minocycline 10.0% 70.0%
Heparin & Drotrecogin Alfa 11.8% 50.0%
Ciprofloxacin & Sucralfate 12.5% 50.0%
Ketorolac Tromethamine & Celecoxib 15.0% 66.7%
Magnesium Hydroxide & Tetracycline 15.4% 76.9%
Sertraline & Linezolid 16.7% 52.6%
Theophylline & Levofloxacin 16.7% 50.0%
Cyclobenzaprine & Tramadol 17.6% 53.8%
Citalopram & Linezolid 21.7% 76.9%
Heparin & Enoxaparin 22.1% 70.4%
Fluoxetine & Epinephrine Continuous Infusion 25.0% 55.0%
Acetylsalicylic Acid & Drotrecogin Alfa 33.3% 60.0%
  • DDI = drug–drug interaction.

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