Table 3
ADE Rules: Positive Predictive Value (Rules with No ADEs Not Listed)
| Rule Description | ADEs | Alerts | PPV |
| Carbamazepine > 14 | 4 | 4 | 1.00 |
| Digoxin > 2.5 | 2 | 2 | 1.00 |
| Flumazenil administered | 2 | 2 | 1.00 |
| Hypoglycemia: glucose < 40 and insulin | 1 | 1 | 1.00 |
| Naloxone administered | 9 | 14 | 0.64 |
| Clostridium difficile infection | 7 | 14 | 0.50 |
| Phenobarbital > 50 | 2 | 6 | 0.33 |
| INR > 4.5 | 5 | 16 | 0.31 |
| Hypokalemia: potassium < 3 | 66 | 223 | 0.30 |
| Tacrolimus > 20 | 1 | 4 | 0.25 |
| Tobramycin trough > 3 | 1 | 4 | 0.25 |
| Hypomagnesemia: Mg2+ < 1.6 | 19 | 80 | 0.24 |
| Vancomycin trough elevated | 5 | 24 | 0.21 |
| Phenytoin > 20 | 3 | 17 | 0.18 |
| Nephrotoxicity: (Scr 2× increase over past 2 days) or (Scientific Review > 1.5x ULN) | 18 | 149 | 0.12 |
| Metabolic acidosis: anion gap > 11 with drug cause | 1 | 9 | 0.11 |
| Hyperkalemia: potassium > 6.5 and age > 1 yr | 2 | 25 | 0.08 |
| Hepatotoxicity: elevated liver function test (2.5x ULN) | 9 | 159 | 0.06 |
| Neutropenia: ANC < lower limit of normal | 2 | 67 | 0.03 |
| Hypophosphatemia: phosphorus < lower limit of normal | 1 | 85 | 0.01 |
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ADE = adverse drug event; INR = international normalized ratio; ULN = upper level of normal.
