rss
J Am Med Inform Assoc 16:768-774 doi:10.1197/jamia.M3023
  • Perspectives on Informatics

Computational Reasoning across Multiple Models

Table 1

Example of Abstraction Layer Elements for the Microsphere Deposition Model in Example II

Property Name Value Type Units Range Description
Parameter:
 Microspere diameter scalar μm The diameter of each micro-particle to be deposited by the model. Allows the model to determine in which vessels the microspheres lodge.
Input:
 Vasculature tree vessel diameter μm [1,∞] Morphology of the blood vessels. The relative diameter of the branches of the same parent determines the proportion of microspheres travelling through each. The position of the branch determines the location of a microsphere cluster in that vessel if there is one.
 Position (x,y,z) 3D point mm x:[−150,150], y:[−150,150], z:[−150,150]
Output:
 Type - value 3D scalar field Proportion [0,1] The output of the model is the lodgement locations of clusters of microspheres in the space of the tumour. The field consists of the location of each cluster and the proportion of the microspheres in it.
 Type - domain 3D point mm x:[−150,150], y:[−150,150], z:[−150,150]
  • The abstraction layer specifies the constant values used in the model (parameters), the types of the variables that the model expects, the units assumed and acceptable range (input), and the form of the output that a simulation using the model calculates. The textual description of each element enables a human modeler to decide how the model can be used in a composition without understanding the internal representations and calculations made by the model.

This Article

Access policy for JAMIA

All content published in JAMIA is deposited with PubMed Central by the publisher with a 12 month embargo. Authors/funders may pay an Unlocked fee of $2,000 to make the article free on the JAMIA website and PMC immediately on publication.

All content older than 12 months is freely available on this website.

AMIA members can log in with their JAMIA user name (email address) and password or via the AMIA website.