Enhancements in healthcare information technology systems: customizing vendor-supplied clinical decision support for a high-risk patient population
- Department of Pharmacy, NewYork-Presbyterian Hospital, Columbia University Medical Center, New York, New York, USA
- Correspondence to Dr Spencer T Martin, Department of Pharmacy, NewYork-Presbyterian Hospital, Columbia University Medical Center, 622 West 168th Street, VC-B, New York, New York 10032, USA;
Contributors All authors contributed to the conception, design, and acquisition of data for analysis and interpretation in the manuscript. All authors took part in drafting the manuscript, including critical revisions for intellectual content. All authors approved the final version for publication.
- Received 3 May 2012
- Accepted 26 June 2012
- Published Online First 19 July 2012
Healthcare organizations continue to adopt information technologies with clinical decision support (CDS) to prevent potential medication-related adverse drug events. End-users who are unfamiliar with certain high-risk patient populations are at an increased risk of unknowingly causing medication errors. The following case describes a heart transplant recipient exposed to supra-therapeutic concentrations of tacrolimus during co-administration of ritonavir as a result of vendor supplied CDS tools that omitted an interaction alert. After review of 4692 potential tacrolimus-based DDIs between 329 different drug pairs supplied by vendor CDS, the severity of 20 DDIs were downgraded and the severity of 62 were upgraded. The need for institution-specific customization of vendor-provided CDS is paramount to ensure avoidance of medication errors. Individualized care will become more important as patient populations and institutions become more specialized. In the future, vendors providing integrated CDS tools must be proactive in developing institution-specific and easily customizable CDS tools.
Competing interests None.
Ethics approval Columbia University Medical Center.
Provenance and peer review Not commissioned; externally peer reviewed.