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J Am Med Inform Assoc 5:305-314 doi:10.1136/jamia.1998.0050305
  • Original Investigation

Identifying Adverse Drug Events

Table 4

Frequency and Positive Predictive Value of Adverse Drug Event (ADE) Monitor Rules

No. Alerts (N) No. Alerts Associated with ADEs (A) Positive Predictive Value (A/N)
Nephrotoxin and rise in creatinine* 375 65 17
Prednisone 313 27 9
Diphenhydramine 300 42 14
Allergy entered 113 21 19
Hydrocortisone 154 16 10
Prednisone and diphenhydramine 111 14 13
Dextrose 50% 100 27 27
Sodium polystyrene sulfate 92 11 12
Oral metronidazole or vancomycin 87 14 16
Serum potassium > 6.5 mmol/L 66 8 12
Serum digoxin > 1.7 ng/mL 61 14 23
Vitamin K and previous warfarin 60 17 28
Serum vancomycin >50 mg/L 54 10 19
Triamcinolone and beta-blocker 51 5 10
Others 683 161 23
Total 2620 450 17

  • ↵* See footnote to appendix (p. 313) for list of drugs included as nephrotoxins.

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