Research Reported in the Literature
| No. in Study | Length of Study | Study Design | Age Group | Disease or Event, and Intervention | Findings Significant for Experimental Group (P < 0.05), Including Effect Sizes (ES) | Findings Significant for All Study Participants* | |
| Fisher et al., 197734 | 99 | 3 wk | Volunteer sample, random group assignment | Adults 18-25 yr | Urine collection | More uniform skill performance, decreased bacterial count (ES 0.33), and decreased procedure problems | |
| Three groups: CAI, text or human instruction | |||||||
| Millstein & Irwin, 198354 | 108 | 5 mo | Randomized (three groups) | Adolescents 14-20 yr | Sexual history | Satisfaction with survey (ES 0.43) | |
| Interview, self-administered questionnaire, or computerized assessment | |||||||
| Wetstone et al., 198547 | 36 | 34 day | Randomized (two groups stratified by education level) | Adults: avg age 50.9 yr | Rheumatoid arthritis | Improved knowledge, improved self-care (joint protection and rest) and hope, improved outlook, and decreased fatalism | Improved self-reported compliance |
| CAI or traditional instruction | |||||||
| Rubin et al., 198632 | 65 | 1 yr | Randomized (two groups) | Children 7-12 yr | Asthma | Improved disease management, health related behaviors (ES 0.72), and knowledge (ES 0.98) | |
| Educational game or entertainment game | |||||||
| Wise et al., 198620 | 174 | 4-6 mo | Randomized (stratified by year and month of birth) | Adults 23-72 yr | Diabetes | Improved knowledge (IDDM group ES 0.41, NIDDM group ES 0.69) and decreased HgbA1 (ES 0.74) | |
| CAI (two different interventions) or traditional instruction | |||||||
| Rippey et al., 198746 | 72 | Pre- and post-test | Convenience | Elderly 52-88 yr | Arthritis | Improved knowledge (ES 0.94) and self-care behaviors (joint rest ES 0.53, heat ES 0.49, relaxation ES 0.64 and exercise ES 0.37) | |
| CAI | |||||||
| Leirer et al., 198841 | 16 | 14 day | Randomized cross-over | Adults: “elderly” | Medication recall | Decreased nonadherence (ES 1.14) | |
| CAI or traditional training | |||||||
| Marrero et al., 198912 | 57 | 4 mo | Randomized (two groups stratified by age and sex) | Adolescents 10-18 yr | Diabetes | Increase in self-reported understanding of treatment, increased perceived importance of testing, improved quality of interaction with physician | Improved HgbA1c |
| One group used glucose meter with data storage; the other used text logs to record glucose values | |||||||
| Horan et al., 19908 | 20 | 15 wk | Randomized (two groups)† | Adolescents 12-19 yr | Diabetes | Improved pre-lunch and pre-dinner blood glucose results | Improved HgbA1c and knowledge |
| CAI plus data management or print material | |||||||
| Huss et al., 199130 | 52 | 12 wk | Randomized (two groups) | Adults 18-75 yr | Atopic asthma | Improved adherence to therapy between CAI and traditional instruction (ES 0.64) | |
| CAI or CAI and traditional instruction | |||||||
| Peters et al., 199116 | 42 | 32 day | Randomized (two groups) | Adults 22-45 yr | Diabetes | Decreased insulin required (ES 0.35) | Improved HgbA1c, decreased hypoglycemia |
| CAI and traditional support for therapy decisions | |||||||
| Turnin et al., 199219 | 105 | 1 yr | Randomized (two groups cross-over) | Adults 42-47 yr | Diabetes | Improved knowledge (ES 1.91), decreased fat intake (ES 0.48), decreased HgbA1 (ES 0.80) | |
| Access to a distributed learning system | |||||||
| Ogozalek, 199315 | 64 | Pre- and post-test | Selection criteria unclear | Elderly 65-75 yr | Medication information | Improved knowledge score with computer and IVD (ES 0.41) and between computer and IVD (ES 1.3) | Improved knowledge with text-based computer |
| Leaflets, text-based computer, or IVD | |||||||
| Meyerhoff et al., 199414 | 24 | 3 yr | Volunteers (three groups), length-of-time meter used | Adults 17-50 yr | Diabetes | Improved HgbA1c (ES 1.12) | |
| Glucose meter with data storage | |||||||
| Osman et al., 199431 | 801 | 1 yr | Randomized (two groups) | Adults 48-51 yr | Asthma | Decreased hospital admission (ES 0.85) | |
| Treatment group received computer-generated books | |||||||
| Liao et al., 199628 | 68 | Pre- and post-test | Volunteers (pilot study) | Adults: avg age 61 yr | Coronary artery disease | Increased confidence in treatment choices | |
| IVD | |||||||
| Madoff et al., 199642 | 42 + 13 from pilot | 3 mo | Randomized (two groups) | Adults: avg age 35 yr | Psychiatric patients | Medication knowledge (ES 1.54) | Improved knowledge retention and medication compliance |
| CAI or traditional instruction | |||||||
| Petersen, 199625 | 15 | Pre- and post-test | Convenience | Children 9-16 yr | Oncology blood counts | Improved knowledge (ES 1.78) | |
| CAI | |||||||
| Brown et al., 19973 | 59 | 6 mo | Randomized (two groups) | Children 8-16 yr | Diabetes | Communication with parents about diabetes (ES 0.21), self-care rating scale (ES 0.37) | Improved HgbA1c and knowledge |
| Educational game or entertainment game | |||||||
| Clark et al., 199727 | 814 | 12 wk | Randomized (two groups) | Adults: “middle age” | Hyperlipidemia | Decreased plasma cholesterol (ES 0.58) | Decreased self-report of consumption of dietary fat and cholesterol |
| CAI or traditional instruction | |||||||
| Evans et al., 199833 | 43 | 18 mo | Convenience sample | Children 8-10 yr | Nocturnal enuresis | Improved knowledge score | |
| CAI pre- and post-test |









