rss
J Am Med Inform Assoc 9:461-471 doi:10.1197/jamia.M1103
  • Focus on Simulation

Modeling and Simulation of Pathways in Menopause

Table 1

Modeling Parameters for the Stochastic Activity Network in Figure 2

Place Names Initial Markings Input Gates Predicates
androstenedione 0 it11 MARK(time)>12 && <19
aromatase 5 it12 MARK(time)>=19
apoptosis1,2 0 it21 MARK(time)<13
cholesterol 100 it22 MARK(time)>15 && <20
estradiol 0 it23 MARK(time)>=20
estrone 0 it24 MARK(time)>12 && <=15
FSH 100 feed1,2 MARK(time)>13
LH 100
progesterone 0
s_a,b,c 1
SCC 40
time GLOBAL_S(cycle_days)
Activity Names Rates
a_e 0.04* MARK(aromatase)
HSD 4
pregnenolone 0.2* MARK(SCC)
up1 0.5* pow(2, MARK(time) – 12)
up2 0.1* pow(2, 0.5* MARK(time))
up3 2 – 0.5* exp(–MARK(time) + 14)
down1 pow(2, 0.7* (MARK(time) – 18))
down2 0.1* pow(2, 0.7* (MARK(time) – 20))
down3 0.1* (MARK(time) – 12)
other1,2 0.2
one, two, three 1000

This Article

Access policy for JAMIA

All content published in JAMIA is deposited with PubMed Central by the publisher with a 12 month embargo. Authors/funders may pay an Unlocked fee of $2,000 to make the article free on the JAMIA website and PMC immediately on publication.

All content older than 12 months is freely available on this website.

AMIA members can log in with their JAMIA user name (email address) and password or via the AMIA website.