Table 4
Major Research Needs for Bioinformatics and Biomedical Computation
| Data Management | Data Analysis | |||
| Develop improved systems for data/information search and retrieval * | Develop Web-based tools locating and integrating information from distributed and diverse database sources * | Develop algorithms for automated image synthesis + | Develop algorithms for analysis of gene and protein array expression patterns for diagnosis of exposure to toxic and biological threats ‡ | NEAR-TERM < 2 years |
| Develop intelligent natural language processing capabilities for database querying ‡ | Develop new networking algorithms to harness the power of thousands of dormant computers + | Develop HPCC systems for medical simulation, visualization, and training * | Develop HPCC systems for modeling molecules and simulating protein structures to improve basic understanding * $ | MID-TERM 2-5 years |
| Establish standard data exchange formats that allows for seamless system interoperability + | Develop innovative database technologies and standard query that accommodate multiple data representations + | Conduct research on predictive algorithms that can handle high-dimensional data in sparse data sets + | Develop algorithms for extracting knowledge from protein primary and tertiary structure information and identify functional markers * $ | |
| Develop a comprehensive biological threat database that transforms dispersed biological threat resources into integrated and interconnected information resources ‡ | Investigate evolutionary programming algorithms capable of automatically writing and debugging software _ | LONG-TERM >5 years | ||
